NIH Consensus Development Conference:
Lactose Intolerance
and Health
February 22–24, 2010
Bethesda, Maryland
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Eunice Kennedy Shriver National Institute of Child Health and Human Development
Office of Medical Applications of Research
of the National Institutes of Health
Co-sponsors
Division of Nutrition Research Coordination
National Institute on Aging
National Institute of Diabetes Digestive and Kidney Diseases
Office of Dietary Supplements
Partners
U.S. Department of Agriculture
The Agency for Healthcare Research and Quality and the Centers for Disease Control and Prevention provided additional conference development support.
Monday, February 22, 2010
| 8:30 a.m. | Opening Remarks Alan E. Guttmacher, M.D. Acting Director Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health |
| 8:40 a.m. | Charge to the Panel Jennifer M. Croswell, M.D., M.P.H. Acting Director Office of Medical Applications of Research Office of the Director National Institutes of Health |
| 8:50 a.m. | Conference Overview and Panel Activities Frederick J. Suchy, M.D. Panel and Conference Chairperson Professor of Pediatrics Chief of Pediatric Hepatology The Jack and Lucy Clark Department of Pediatrics Mount Sinai School of Medicine of New York University Mount Sinai Kravis Children’s Hospital |
| Overview of the Topic | |
| 9:00 a.m. | Early Feeding, Human Milk, and the Transition Josef Neu, M.D. Professor Department of Pediatrics University of Florida College of Medicine |
| 9:20 a.m. | Nutritive Value of Milk and Alternative Sources Nancy F. Krebs, M.D., M.S. Professor of Pediatrics and Head of Section of Nutrition Department of Pediatrics Health Sciences Center University of Colorado at Denver |
| 9:40 a.m. | Cellular and Molecular Biology of Lactase Eric Sibley, M.D., Ph.D. Associate Professor Divison of Pediatrics-Gastroenterology Stanford University School of Medicine |
| 10:00 a.m. | Discussion |
| 10:30 a.m. | What is Lactose Intolerance and How to Measure It Richard J. Grand, M.D. Professor of Pediatrics Harvard Medical School Program Director Clinical and Translational Study Unit Director Center for Inflammatory Bowel Disease Children's Hospital Boston |
| 10:50 a.m. | Clinical Presentation and Approach: But What if It Is Not Lactose Intolerance? Lin Chang, M.D. Codirector Center for Neurobiology of Stress Professor of Medicine David Geffen School of Medicine University of California, Los Angeles |
| 11:10 a.m. | Discussion |
| I. | What is the Prevalence of Lactose Intolerance, and How Does This Prevalence Differ by Race, Ethnicity, and Age? |
| 11:30 a.m. | Population Genetics: Evolutionary History of Lactose Tolerance in Africa Sarah A. Tishkoff, Ph.D. Associate Professor Departments of Genetics and Biology David and Lyn Silfen University University of Pennsylvania |
| 11:50 a.m. | Lactose Intolerance and Ethnic Prevalence Wilma J. Wooten, M.D., M.P.H. President San Diego Chapter National Medical Association San Diego County Health Officer |
| 12:10 p.m. | Lunch Panel Executive Session |
| 1:10 p.m. | Aging: Lactose Intolerance and Calcium Absorption in the Elderly Richard J. Wood, Ph.D. Associate Professor Department of Nutrition School of Public Health & Health Sciences University of Massachusetts |
| 1:30 p.m. | Evidence-based Practice Center (EPC) Presentation I: Methods of Systematic Review and the Prevalence of Lactose Intolerance and Differences by Race, Ethnicity, and Age Timothy J. Wilt, M.D., M.P.H. Codirector Minnesota Evidence-based Practice Center Core Investigator Minneapolis Veterans Affairs Center for Chronic Disease Outcomes Research Professor of Medicine University of Minnesota School of Medicine |
| 1:50 p.m. | Discussion |
| II. | What are the Health Outcomes of Dairy Exclusion Diets? |
| 2:30 p.m. | Consequences of Excluding Dairy, Milk Avoiders, Calcium Requirements in Children Connie M. Weaver, Ph.D. Distinct Professor and Head College of Consumer and Family Sciences Department of Foods and Nutrition Purdue University |
| 2:50 p.m. | Consequences of Excluding Dairy or of Avoiding Milk in Adults Robert P. Heaney, M.D., FACP, FACN John A. Creighton University Professor Professor of Medicine Osteoporosis Research Center School of Medicine Creighton University |
| 3:10 p.m. | Evidence-based Practice Center Presentation II: The Bone Health Outcomes of Dairy Exclusion Diets Timothy J. Wilt, M.D., M.P.H. Codirector Minnesota Evidence-based Practice Center Core Investigator Minneapolis Veterans Affairs Center for Chronic Disease Outcomes Research Professor of Medicine University of Minnesota School of Medicine |
| 3:30 p.m. | Discussion |
| III. | What Amount of Daily Lactose Intake is Tolerable in Subjects with Diagnosed Lactose Intolerance? |
| 4:00 p.m. | Adaptation to Lactose Intolerance Andrew Szilagyi, M.D., FACN, FRCPC Assistant Professor of Medicine McGill University School of Medicine Department of Medicine Division of Gastroenterology The Sir Mortimer B. Davis Jewish General Hospital |
| 4:20 p.m. | Dosing, Symptoms, Tolerable Doses of Lactose Dennis A. Savaiano, Ph.D. Professor and Dean College of Consumer and Family Sciences Department of Foods and Nutrition Purdue University |
| 4:40 p.m. | Evidence-based Practice Center Presentation III: The Tolerable Amount of Lactose Intake in Subjects With Diagnosed Lactose Intolerance Michael Levitt, M.D. Professor Minneapolis Veterans Affairs Medical Center Division of Gastroenterology Department of Medicine University of Minnesota |
| 5:00 p.m. | Discussion |
| 5:30 p.m. | Adjournment |
Tuesday, February 23, 2010
| IV. | What Strategies are Effective in Managing Individuals with Diagnosed Lactose Intolerance? |
| 8:30 a.m. | Prebiotics and Lactose Intolerance David S. Newburg, Ph.D. Associate Professor of Pediatrics Harvard Medical School Director Program in Glycobiology, Pediatric Gastroenterology and Nutrition Massachusetts General Hospital |
| 8:50 a.m. | Strategies for Managing Individuals With Diagnosed Lactose Intolerance: Probiotics Mary Ellen Sanders, Ph.D. Consultant Dairy and Food Culture Technologies Executive Director International Scientific Association for Probiotics and Prebiotics |
| 9:10 a.m. | Treatment Recommendations in Adults With Diagnosed Lactose Intolerance Jeanette N. Keith, M.D. Associate Professor Department of Nutrition Sciences Department of Medicine University of Alabama at Birmingham |
| 9:30 a.m. | Treatment Recommendations in Children Catherine M. Gordon, M.D., M.Sc. Director Children's Hospital Bone Health Program Adolescent/Young Adult Medicine and Endocrinology Children's Hospital Boston Associate Professor of Pediatrics Harvard Medical School |
| 9:50 a.m. | Discussion |
| 10:30 a.m. | Evidence-based Practice Center Presentation IV: Effective Strategies for the Management of Individuals With Diagnosed Lactose Intolerance Aasma Shaukat, M.D., M.P.H. Investigator Minneapolis Veterans Affairs Medical Center Division of Gastroenterology Department of Medicine University of Minnesota |
| 10:50 a.m. | Behavioral Factors Related to Lactose Intolerance and Bone Consequences |
| 11:10 a.m. | Psychological Impacts: Strategies Effective in Managing Individuals Diagnosed With Lactose Intolerance Janet E. Taylor, M.D., M.P.H. Psychiatrist Private Practice |
| 11:30 a.m. | Discussion |
| 12:00 p.m. | Adjournment |
Wednesday, February 24, 2010
| 9:00 a.m. | Presentation of the Draft Consensus Statement |
| 9:30 a.m. | Public Discussion |
| 11:00 a.m. | Adjournment Panel Meets in Executive Session |
| 2:00 p.m. | Press Telebriefing |
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