Terms
- Activity Codes (Funding Mechanisms)
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Activity codes are three-digit alphanumeric combinations that identify a specific category of extramural activity or mechanism of support. The NIH has more than 100 research support mechanisms. For a comprehensive list of activity codes, see: http://grants.nih.gov/grants/funding/ac_search_results.htm.
- Ad Hoc Review
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Review of application(s) or contract(s) by experts selected on a temporary basis for their expertise and experience.
- See Also Special Emphasis Panel
- Administration for Children and Families ACF
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The ACF, within the Department of Health and Human Services, is responsible for federal programs that promote the economic and social well-being of families, children, individuals, and communities.
- Administrative Expenses
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Expenses incurred for the support of activities relevant to the award of grants, contracts, and cooperative agreements and expenses incurred for general administration of the scientific programs and activities of the National Institutes of Health.
- Administrative Notes (in Summary Statements)
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Additional comments/concerns that may be included in Summary Statements (SS).
- See Also Summary Statement
- Administrative Requirements
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The general business management practices that are common to the administration of all grants, such as financial accountability, reporting, equipment management, and retention of records.
- Administrative Resource Center ARC
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The areas the ARC assist with are budget, travel, procurement and space management. The ARC manager reports to the Deputy Associate Director, Office of Management , NCI. The ARC mission statement says that the ARC is to be a recognized leader in the field of administration, providing the highest quality customer service available to our NCI programs whose ultimate goal is to find a cure for cancer. To this end, we strive to provide expert, confidential, and efficient administrative service with professionalism, integrity and compassion.
- Administrative Supplement
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Funds added to a grant without peer review to pay for items within the scope of an award but unforeseen when a grant application was submitted
- Advance
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A payment made by Treasury check or other appropriate payment mechanism to a recipient upon its request either before cash disbursements are made by the recipient or through the use of predetermined payment schedules.
- Advance Agreement
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Agreement negotiated before a contractor incurs a cost, specifying whether a cost is allowable. An advance agreement may be negotiated before or during a contract and must be in writing. Advance agreements may be specific to a contract, group of contracts, or all contracts of a contracting office, agency, or several agencies.
- Advance Copies
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In most cases, the Referral Officer will deliver these copies of applications provided by applicant(s) to the appropriate Scientific Review Administrator and Program Director.
- Adverse effect
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Unanticipated problem or unfavorable symptom or disease occurring during a clinical study, though not necessarily caused by the study treatment, which harms subjects or others, for example, a loss of research records, drug overdose, serious symptom, or death. Go to 45 CFR part 46, subpart A.
- Adverse event
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Any unfavorable and unintended sign (including an abnormal laboratory finding), symptom or disease temporally associated with the use of a medical treatment or procedure regardless of whether it is considered related to the medical treatment or procedure.
- Adverse Event Expedited Reporting System AdEERS
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An electronic system for expedited submission of adverse event reports that is used by the NCI Clinical Trials Evaluation Program.
- Adverse Events Reporting
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Adverse event collection and reporting is a routine part of every clinical trial. The first step is to identify the event using the Common Toxicity Criteria (CTC). The severity of the event should then be graded using the CTC criteria. Next, determine if the adverse event is related to the medical treatment or procedure (attribution). If so, determine whether the adverse event is expected or unexpected. With this information and the adverse event reporting section in each protocol, the investigator can determine whether an adverse event should be reported to the NCI as an expedited report (AdEERS) or a routine report (CDUS or CTMS).
- Advisory Committee of the Director ACD
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Provides advice and recommendations for the oversight of specific programs to the Director of an NIH Institute or Center; there is an ACD in the NCI.
- Advisory Council
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Chartered Institute advisory committee that performs the second level of peer review, makes funding and policy recommendations, and helps develop research initiatives. In the NCI, this council is called the National Cancer Advisory Board.