REDS Allogeneic Donor and Recipient Repository (RADAR)
Prepared on November 18, 2008
Study Dates: 2000-2003
Consent: Restricted Consent
Consent Restrictions: Research restricted to transfusion transmissible infectious agents
Commercial Use Restrictions: No
NHLBI Division: DBDR
Collection Type: Open BioLINCC Study - See bottom of this webpage for request information
Determine if newly identified or emerging pathogens can be transmitted by transfusion.
Earlier repositories such as the NHLBI-sponsored Transfusion-Transmitted Virus Study (TTVS) and the National Institutes of Health Clinical Center repository were vital to the investigation of viral hepatitis transmission following blood transfusion. Based on the success of these collections it was determined that a more contemporary donor-recipient repository was needed. The Retrovirus Epidemiology Donor Study (REDS) has been conducted since 1989. In the late 1990's it was commissioned to establish a new linked donor-recipient repository.
A total of 127,864 donation specimens were collected from 101,197 different donors. The majority are not linked to any recipient specimens in the repository. The repository contains 13,201 donation specimens from 12,408 donors that were transfused into 3,575 recipients who completed the follow-up visit (1). Specimens consist of plasma (in most cases) or serum and frozen whole blood samples.
The REDS Allogeneic Donor and Recipient (RADAR) repository was established between 2000 and 2003 by 5 REDS blood centers, 2 CDC-supported blood centers and eight collaborating hospitals with a wide US geographical distribution. Specimens from consented donors were collected, components from their donations were routed to participating hospitals, and recipients of these units consented to provide enrollment and follow-up specimens for long-term storage. (1).
At the time of its completion, RADAR was the largest linked donor-recipient repository in the US. It was designed to be of sufficient size to study the transfusion transmissibility of emerging infectious agents (1).
1. Kleinman SH, et al. (2005) The RADAR repository: a resource for studies of infectious agents and their transmissibility by transfusion. Transfusion 45(7):1073-1083.