PQ - 2 What environmental factors change the risk of various cancers when people move from one geographic region to another? Background: Numerous studies have identified associations between the incidence of various cancers and local living conditions. There are many well-documented examples of cancer incidence changing as populations migrate from one site to another. These migrating populations will often adopt the cancer incidence profiles of their new host locale. In these instances, it is likely that environmental or cultural influences are contributing to the increased incidence of various cancers. Early studies identified this phenomenon and confirmed these relationships, but continued work on the identification of risk factors in migrating populations has languished in recent years. This question seeks to stimulate more sophisticated studies on epidemiological risk identified through studies of migration. Feasibility: The methodologies for these studies are well established; however, with more complicated migration patterns seen in our model global economy, it may be necessary to consider more sophisticated metrics of population remodeling. Implications of success: If new factors that contribute to changes in cancer incidence in migrating populations can be identified, our understanding of environmental carcinogenesis would be significantly enhanced. This information could have important implications for understanding cancer etiology, pathogenesis, and prevention. |
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