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The Adult and Adolescent ARV Guidelines were updated on February 12, 2013. Please send your comments with the subject line "Comments on Adult and Adolescent ARV Guidelines" to ContactUs@aidsinfo.nih.gov by February 26, 2013.
(Last updated:2/12/2013; last reviewed:2/12/2013)
Appendix B, Table 4. Characteristics of Integrase Inhibitors Click here to view this table as an image
Generic Name (Abbreviation)/ Trade Name
Formulations
Dosing Recommendations (For dosage adjustment in hepatic insufficiency, see Appendix B, Table 7.)
Serum Half-Life
Route of Metabolism
Adverse Events (Also see Table 13.)
With rifampin: 800 mg BID
Take without regard to meals.
Stribild
Not recommended for patients with baseline CrCl< 70 mL/min. See Appendix B Table 7 for the equation for calculating CrCl.
Not recommended for use with other antiretroviral drugs
COBI: CYP3A, CYP2D6 (minor)