NCI Resources and Services

Name	Biophysics Resource (Structural Biophysics Laboratory, CCR)
Expertise	Expertise in characterizing the biophysical aspects of systems under structural investigation.
Location	Building 538, Room 172, NCI-Frederick
Fee Structure	Note: *There is a one-time access fee for unlimited use of all technologies throughout fiscal year.*

Name	Mass Spectrometry Center (MSC) (Advanced Technology Program, SAIC-Frederick)
Expertise	Areas of expertise include protein complex characterization, global and target protein quantitation, and identification of post-translational modifications. The Center also provides educational and training opportunities for scientists on the use, interpretation, and applications of MS technologies.
Location	Building 469, Room 160, NCI-Frederick
Fee Structure

Name	Molecular Modeling Core (Laboratory of Cell Biology, CCR)
Expertise	Molecular modeling of membrane proteins, transporter proteins, and the interactions that regulate the p53 protein.
Location	Building 37, Room 3035B, Bethesda
Fee Structure

Name	Nuclear Magnetic Resonance (NMR) Group (Advanced Technology Program, SAIC-Frederick)
Expertise	Expertise in NMR experimentation and analysis using the most current hardware and software. This group provides characterization of individual small molecules as well as metabolomic analysis for the comparative analysis of complex mixtures of metabolites in clinical samples such as serum and urine. Members of this group also have extensive experience in electronics engineering, pulse sequence programming, and database access.
Location	Building 469, Room 160, NCI-Frederick
Fee Structure

Name	Protein Chemistry Laboratory (Advanced Technology Program, SAIC-Frederick)
Expertise	Surface plasmon resonance (SPR) spectroscopy and fluorescence and complementary chemistry techniques for protein identification, including mass spectrometry (MS) and classic Edman protein sequencing. The lab has state-of-the-art MALDI-TOF mass spectrometry with imaging and high mass detection capabilities. The laboratory also provides HPLC purification and quality control of protein and oligonuleotides.
Location	Building 469, Room 241, NCI-Frederick
Fee Structure

Name	Radiolabeled Compounds Repository (Developmental Therapeutics Program, NCI)
Expertise	NCI's inventory of radiolabeled compounds is available to qualified researchers. These radiolabeled drugs are from the Drug Synthesis and Chemistry Branch, Developmental Therapeutics Program (DTP).
Location	Suite 8030, Executive Plaza North (EPN), Rockville
Fee Structure

Name	Synchrotron Radiation Research Section (Macromolecular Crystallography Laboratory, CCR)
Expertise	Development of new methods for phasing macromolecular structures by anomalous scattering and extending the resolution of crystal structures to atomic levels.
Location	Building 202, Room Q142, Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439
Fee Structure

Name	Separations Technology Group (Advanced Technology Program, SAIC-Frederick)
Expertise	Development of highly accurate quantitative assays for specific molecules of interest. Innovative methods for separation and quantitation of analytes using gas chromatography (GC), high-performance liquid chromatography (HPLC), and capillary electrophoresis (CE) online with various detection methods such as mass spectrometry (MS) and ultraviolet (UV).
Location	Building 469, Room 160, NCI-Frederick
Fee Structure